Tunahan Çakır, Group Leader
Associate Professor
Gebze Technical University |
![]() Detailed CV |
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Department of Bioengineering | ||
Computational Systems Biology Group | ||
Gebze-Kocaeli | ||
TURKEY | ||
Mail: | tcakir [at] gtu.edu.tr | |
Room: | Bioengineering Building, 146 | |
Phone: | +90 262 605 33 20 | |
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Introduction
I have received my B.Sc, M.Sc and Ph.D degrees from Department of Chemical Engineering at Bogazici University, Istanbul. My PhD thesis research mainly involved integrative analysis of omics data (metabolomics and transcriptomics) and metabolic networks, and it was partly a collaborative project with Prof. Jens Nielsen. For my post-doctoral project at the Biosystems Data Analysis Group (University of Amsterdam) and at the Department of Metabolic and Endocrine Diseases (University Medical Center Utrecht), I worked on the inference of underlying metabolic network structures from metabolome data.
Currently, I am a group leader in Computational Systems Biology group at Department of Bioengineering in Gebze Technical University, TURKEY. I am one of the co-founders of the start-up company PHI Tech Bioinformatics since 2013. I act as a reviewer, among others, for journals Bioinformatics, Molecular Omics, Plos Computational Biology. I am an advisory board member of the journal Molecular Omics, published by Royal Society of Chemistry, as of September 2015. I am a recipient of 2015 GEBIP (Young Scientist Outstanding Achievement Award) award by Turkish Academy of Sciences (TUBA) and and Research Incentive Award by METU Prof. Mustafa Parlar Foundation (2017).
Research Areas
My research focuses on mapping genome-wide omics data on molecular interaction networks (protein protein interaction networks, genome scale metabolic networks) using computational systems biology methods to elucidate molecular mechanisms of neurodegenerative diseases (Alzheimer's Disease, Parkinson's Disease), infectious diseases and cancer. To this aim, we apply a number of bioinformatics methods to predict potential biomarkers, drug targets and drugs for those diseases. Our main interest is to map disease-associated transcriptome data on molecular interaction networks to shed light on molecular & metabolic mechanisms.
Ongoing Research Projects
- Processing RNA-sequencing data for Alzheimer's Disease to develop personalized molecular interaction network models and to elucidate disease mechanisms (Collaborator: Madhav Thambisetty, NIH, National Institute of Aging, USA)
- Bioinformatic analysis of transcriptome data and cellular networks for Parkinson's Disease: Identification of novel drug targets and drugs (Collaborator: Işıl Aksan-Kurnaz, Gebze Technical University, TURKEY)
- Creation of dormancy models of non-small cell lung cancer and investigation of its pathogenesis via omics approaches (Collaborator: Devrim Gözüaçık, Koç University, TURKEY)
- Constraint-based and Structure-based Analysis of Metabolic Pathways to Identify Potential Drug Targets against the Lethal Infectious Diseases originating from K. pneumoniae and S. enterica (Collaborator: Reaz Uddin, ICCS, University of Karachi, PAKISTAN)
Teaching
- Fundamentals of Systems Biology: MSc Course in Bioinformatics and Systems Biology Program
- Systems Neuroscience: PhD Course in Bioinformatics and Systems Biology Program
- Genome Scale Metabolic Models: PhD Course in Bioinformatics and Systems Biology Program
- Foundations of Mathematical Modelling in Biology: PhD Course in Bioinformatics and Systems Biology Program
- Advanced Bioinformatics with R: PhD Course in Bioinformatics and Systems Biology Program
Selected Publications
For a full list of publications, see PUBLICATIONS page.
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Novel Approaches for Systems Biology of Metabolism-Oriented Pathogen-Human Interactions: A Mini-Review
- Frontiers in Cellular and Infection Microbiology, 10:52 (2020)
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JacLy: a Jacobian-based method for the inference of metabolic interactions from the covariance of steady-state metabolome data
- PeerJ, 6:e6034 (2018)
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Reconstructed metabolic network models predict flux-level metabolic reprogramming of glioblastoma
- Frontiers in Neuroscience, 10:156 (2016)
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Reporter pathway analysis from transcriptome data: Metabolite-centric versus Reaction-centric approach
- FEBS Open Bio, 5:14563 (2015)
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Systematic Analysis of Transcription-Level Effects of Neurodegenerative Diseases on Human Brain Metabolism by a Newly Reconstructed Brain-Specific Metabolic Network
- FEBS Open Bio, 4:542-553 (2014)
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Infection strategies of bacterial and viral pathogens through pathogen-host protein-protein interactions
- Frontiers in Microbiology, 3:46 (2012)
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Metabolic network discovery through reverse engineering of metabolome data
- Metabolomics, 5: 318-329, (2009)
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Integration of metabolome data with metabolic networks reveals reporter reactions
- Molecular Systems Biology, 2:50 (2006)